Charkit
provides custom synthesis capabilities, contract manufacturing
of APIs, and advanced intermediates to pharmaceutical companies
worldwide. Charkit’s pharmaceutical resources are comprised
of a worldwide supplier network enhanced by exclusive
agreements with our affiliate companies, Arran Chemical
Company in Ireland and Optima Chemical Group LLC in the United
States.
Substantial
resources are dedicated to process development and contract
manufacturing. Some of our core technologies include: low
temperature reactions (to -70 °C), high temperature reactions
(to 250 °C), organometallic reactions (including Grignard
chemistry and alkali metal reactions), solvent free reactions,
phase transfer catalysis, polymer extractions, hydrogen peroxide
chemistry, hydrazine handling and derivatives, chiral chemistry
(asymmetric synthesis, resolutions, asymmetric building blocks),
and silylation.
Our manufacturers’
facilities feature cGMP manufacturing, FDA inspected pilot
plants and commercial scale equipment, as well as an FDA inspected
kilo lab.
We can also
offer support services such as polymorph analysis and determination,
method validation, critical parameter studies, stability studies,
etc. which provide added value to many of our pharmaceutical
partners.
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Suzuki
Coupling technology, a popular tool in pharmaceutical synthesis,
utilizes boronic acid derivatives as the key starting
material. Optima produces over 150 derivatives from lab to commercial
scale to support this growing technology platform. Some of these
derivatives include:
- Phenylboronic
acid
- Formyl
phenylboronic acids
- n-Butyl
boronic acid
- n-Hexyl
boronic acid
- Carboxy
phenylboronic acids
- Fluoro
phenylboronic acids
- Furanboronic
acids
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- Methoxy
phenylboronic acids
- Tolylboronic
acids
- Chloro
phenylboronic acids
- 4-(methylthio)phenylboronic
acid
- Napthaleneboronic
acids
- Nitro
phenylboronic acids
- Thiopheneboronic
acids
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Extensive
lines of excipients, reagents, and other intermediates that
have pharmaceutical applications are also available through
Charkit. You can find a list of our key suppliers and their
product areas in the Supplier
Relationships section
of our website.
Contact
us to find out more.
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